Postdoctoral Associate, Pathology & Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine

Our laboratory invites applications for a postdoctoral associate focused on defining the molecular and cellular mechanisms by which bacterial infections drive lymphatic vessel dysfunction and lymphedema progression.

The successful candidate will contribute to a multidisciplinary project employing the following methods:

• 1.
• Characterization of molecular and cellular perturbations caused by S. aureus strains using single-cell transcriptomics and lineage tracing in murine models of cutaneous infection and lymphatic vessel dysfunction.
• 2.
• Delineation of infection-associated signaling cascades and testing the efficacy of pharmacological agents to restore contractile function of lymphatic vessels.
• 3.
• Evaluation of the impact of S. aureus toxins on lymphatic vessel dynamics through high-resolution functional imaging.
• 4.
• Investigation of targeted inhibition of S. aureus toxins on lymphatic function and host antimicrobial immunity in vivo to determine protective potential against recurrent infections.

Responsibilities: The postdoctoral associate will spend at least 80% of their time on research activities, including:

• 1.
• Design and execution of murine infection models and assessment of lymphatic vessel function.
• 2.
• Performance of single-cell RNA sequencing, lineage tracing, and high-resolution calcium imaging experiments.
• 3.
• Analysis and interpretation of transcriptomic, imaging, and functional data.
• 4.
• Testing pharmacological interventions and bacterial toxin inhibitors in vivo.
• 5.
• Collaboration with clinical and translational research teams.
• 6.
• Co-authoring manuscripts, presenting findings at scientific conferences, and contributing to grant preparation.

The remaining 20% may include

1. Mentoring graduate students and research assistants. 2. Participating in laboratory meetings, journal clubs, and institutional seminars. 3. Contributing to manuscript and grant writing efforts.

Appointment Details

Duration