City of Hope·Duarte, California
The postdoctoral fellow will investigate the homeostasis of uridine and its role in the pathophysiology of obesity, diabetes, and cancer using genetically engineered mouse models and in vitro systems. Research will focus on the role of uridine in disease progression, its physiology in bile and nutrient absorption, and its regulation by ER stress relevant to breast cancer.
Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses.
Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.
A postdoctoral position is open in the laboratory of Yingfeng Deng in the Department of Diabetes and Cancer Metabolism at the City of Hope Beckman Research Institute.
The Deng laboratory studies the homeostasis of uridine and its role in metabolism, which provides a new angle for understanding the pathophysiology of obesity, diabetes and cancer.
Work in the lab utilizes both genetically engineered mouse models and in vitro systems.
A combination of state-of-the-art surgical, genetic, cellular, biochemical, imaging, and metabolic flux approaches is currently used in the lab.
Following up with the new paradigm revealed about uridine metabolism by Drs.
Deng and Scherer (Science, 2017), the Deng lab is currently focusing on three areas: 1) the role of uridine in the progression of obesity and diabetes.
2) the physiology of uridine in bile and nutrient absorption.
3) the regulation of uridine homeostasis by ER stress and its relevance to breast cancer.
We seek an independent and highly motivated candidate interested in studying the molecular, cellular, and metabolic mechanisms leading to obesity, diabetes, and cancer.
Expertise in using mouse models to study metabolic diseases is preferred.
For a complete list of Publications please visit here: https://www.ncbi.nlm.nih.gov/myncbi/1J54E41I5YVku/bibliography/public/
Candidates must possess a Ph.D. and/or M.D. degree in life or biomedical sciences or a related discipline. Preferred qualifications include expertise in using mouse models to study metabolic diseases, along with experience in basic molecular biology, animal models, lipid metabolism, metabolomics, and liver physiology.
Market context
California postdoctoral roles in diabetes and cancer metabolism are typically competitive because they sit at the intersection of translational research, animal models, and molecular analysis. This position favors candidates with a Ph.D. and/or M.D., plus experience with mouse models, basic molecular biology, animal studies, and lipid or metabolomics work. On this platform, the job requirements and benefits are AI-summarized from the original posting, which can save you time when comparing fit; if you apply, tailor your materials to show direct experience with metabolic disease research and mouse-based experiments.