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Clinical Research Associate II

ICON plc·Chicago, Illinois

$91,336 - $114,170/yr·Full Time·Remote Ok·Remote friendly·2-5 yrs
·Posted 4 days ago
Practice for this role

About the role

The Clinical Research Associate serves as the primary point of contact for investigational sites, conducting site visits to ensure compliance with ICH-GCP and regulatory standards. They are responsible for monitoring patient safety, managing site documentation, and overseeing drug accountability throughout the clinical trial process.

Clinical Research Associate - Oncology - Chicago

ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments to patients faster.

As a values-driven organisation, integrity, collaboration, agility, and inclusion are at the heart of how we work and interact with each other, customers, patients and suppliers.

What You Will Be Doing

  • Serve as the primary point of contact between investigational sites and the sponsor
  • Conduct all types of site visits, including selection, initiation, routine monitoring, and close-out
  • Ensure site compliance with ICH-GCP, SOPs, and regulations
  • Maintain up-to-date documentation in CTMS and eTMF systems
  • Support and track site staff training and maintain compliance records
  • Monitor patient safety, ensuring timely and accurate AE/SAE/PQC reporting
  • Support subject recruitment and retention efforts at the site level
  • Oversee drug accountability and ensure proper storage, return, or destruction
  • Resolve data queries and drive timely, high-quality data entry
  • Document site progress and escalate risks or issues to the clinical team
  • Assist in tracking site budgets and ensuring timely site payments (as applicable)
  • Collaborate with cross-functional partners including CTAs, LTMs, and CTMs

You are

  • A graduate with a Bachelor’s degree in Life Sciences or equivalent preferred, or a qualified RN
  • Eligible to work in United States without visa sponsorship
  • A clinical research professional with 2+ years of on-site monitoring experience in the pharmaceutical or CRO industry
  • Experience monitoring Oncology clinical trials required, preferably heme/onc
  • Proficient in ICH-GCP, local regulatory requirements, and clinical systems like CTMS and eTMF
  • A clear communicator, problem-solver, and collaborative team player
  • Willing and able to travel up to 50% for on-site monitoring visits across southeast region; preference given to candidates residing in Chicago near major HUB airports to support efficient regional travel

Employment with ICON is contingent upon having the legal right to work in the country where the role is based.

Rewards & Benefits

ICON offers a competitive and comprehensive total rewards package designed to support your health, wellbeing, and career development.

Benefits

may include:

  • Competitive base salary and performance related incentives
  • Health and wellbeing programmes including medical, dental, and vision coverage where applicable
  • Retirement and pension plans
  • Life assurance and disability coverage
  • Employee assistance programmes and wellbeing resources
  • Learning and development opportunities through structured training and career pathways

Benefits

may vary depending on role and location.

Visit our careers site [https://careers.iconplc.com/benefits] to read more about the benefits ICON offers.

Inclusion and Accessibility

ICON is an equal opportunity employer. We are committed to building an inclusive and accessible workplace where everyone feels valued and supported.

If you require reasonable accommodations during the recruitment process, please let us know or submit a request here [https://careers.iconplc.com/reasonable-accommodations].

Salary Range

$91,336.00-$114,170.00

Are you a current ICON Employee? Please click here [https://wd3.myworkday.com/icon/d/task/1422$1235.htmld] to apply

Requirements

Candidates must have a Bachelor’s degree in Life Sciences or be a qualified RN, with at least 2 years of on-site monitoring experience in the pharmaceutical or CRO industry. Proficiency in Oncology clinical trials and familiarity with clinical systems like CTMS and eTMF are required.

  • bachelor degree
  • Communication
  • Collaboration
  • Problem-solving
  • Oncology
  • eTMF
  • CTMS
  • ICH-GCP
  • Patient safety
  • Clinical research
  • Regulatory requirements
  • Site compliance
  • Site monitoring
  • AE/SAE reporting
  • Drug accountability
  • Data query resolution

Posting details

Employment type
Full Time
Work arrangement
Remote Ok
Experience
2-5 yrs
Salary
$91,336 - $114,170/yr
Locations
Chicago, Illinois; Blue Bell, South Dakota
Posted
Jul 24, 2026
Application
Employer website
IP

Hiring organization

ICON plc

Since our foundation in Dublin, Ireland in 1990, our mission has been to help our clients to accelerate the development of drugs and devices that save lives and improve quality of life. We do this by delivering best in class information, solutions and performance, with an...

Salary listed on 16 jobs
IndustryBiotechnology Research
TypePublic Company
Size10,001+ employees
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Market context

Illinois CRA II roles stay competitive

Clinical Research Associate II openings in Illinois are often driven by ongoing pharmaceutical and CRO trial activity, especially in oncology. These roles are competitive because employers usually want a Life Sciences degree or RN background, at least 2 years of on-site monitoring experience, and comfort with CTMS and eTMF systems. If you are considering applying, quickly map your oncology monitoring experience to the posting and note that the job requirements and benefits here are AI-summarized from the original description, saving research time.

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