The Clinical Research Associate serves as the primary point of contact for investigational sites, conducting site visits to ensure compliance with ICH-GCP and regulatory standards. They are responsible for monitoring patient safety, managing site documentation, and overseeing drug accountability throughout the clinical trial process.
Clinical Research Associate - Oncology - Chicago
ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments to patients faster.
As a values-driven organisation, integrity, collaboration, agility, and inclusion are at the heart of how we work and interact with each other, customers, patients and suppliers.
What You Will Be Doing
Serve as the primary point of contact between investigational sites and the sponsor
Conduct all types of site visits, including selection, initiation, routine monitoring, and close-out
Ensure site compliance with ICH-GCP, SOPs, and regulations
Maintain up-to-date documentation in CTMS and eTMF systems
Support and track site staff training and maintain compliance records
Monitor patient safety, ensuring timely and accurate AE/SAE/PQC reporting
Support subject recruitment and retention efforts at the site level
Oversee drug accountability and ensure proper storage, return, or destruction
Resolve data queries and drive timely, high-quality data entry
Document site progress and escalate risks or issues to the clinical team
Assist in tracking site budgets and ensuring timely site payments (as applicable)
Collaborate with cross-functional partners including CTAs, LTMs, and CTMs
You are
A graduate with a Bachelor’s degree in Life Sciences or equivalent preferred, or a qualified RN
Eligible to work in United States without visa sponsorship
A clinical research professional with 2+ years of on-site monitoring experience in the pharmaceutical or CRO industry
Proficient in ICH-GCP, local regulatory requirements, and clinical systems like CTMS and eTMF
A clear communicator, problem-solver, and collaborative team player
Willing and able to travel up to 50% for on-site monitoring visits across southeast region; preference given to candidates residing in Chicago near major HUB airports to support efficient regional travel
Employment with ICON is contingent upon having the legal right to work in the country where the role is based.
Rewards & Benefits
ICON offers a competitive and comprehensive total rewards package designed to support your health, wellbeing, and career development.
Benefits
may include:
Competitive base salary and performance related incentives
Health and wellbeing programmes including medical, dental, and vision coverage where applicable
Retirement and pension plans
Life assurance and disability coverage
Employee assistance programmes and wellbeing resources
Learning and development opportunities through structured training and career pathways
Candidates must have a Bachelor’s degree in Life Sciences or be a qualified RN, with at least 2 years of on-site monitoring experience in the pharmaceutical or CRO industry. Proficiency in Oncology clinical trials and familiarity with clinical systems like CTMS and eTMF are required.
bachelor degree
Communication
Collaboration
Problem-solving
Oncology
eTMF
CTMS
ICH-GCP
Patient safety
Clinical research
Regulatory requirements
Site compliance
Site monitoring
AE/SAE reporting
Drug accountability
Data query resolution
Posting details
Employment type
Full Time
Work arrangement
Remote Ok
Experience
2-5 yrs
Salary
$91,336 - $114,170/yr
Locations
Chicago, Illinois; Blue Bell, South Dakota
Posted
Jul 24, 2026
Application
Employer website
Market context
Illinois CRA II roles stay competitive
Clinical Research Associate II openings in Illinois are often driven by ongoing pharmaceutical and CRO trial activity, especially in oncology. These roles are competitive because employers usually want a Life Sciences degree or RN background, at least 2 years of on-site monitoring experience, and comfort with CTMS and eTMF systems. If you are considering applying, quickly map your oncology monitoring experience to the posting and note that the job requirements and benefits here are AI-summarized from the original description, saving research time.
