MASONIC MEDICAL RESEARCH INSTITUTE·City of Utica, New York
The fellow will conduct research on transcriptional and post-transcriptional regulation in cardiovascular development using mouse genetics and multi-omics techniques. The goal is to map cardiac gene regulation networks to understand molecular mechanisms of heart diseases like LVNC.
Description Postdoctoral Research Fellow - Wu Lab The Wu laboratory at the Masonic Medical Research Institute (MMRI) is seeking a highly motivated postdoctoral fellow to delve into multiple exciting projects to understand transcriptional and post-transcriptional regulation in heart disease.
Our laboratory combines mouse genetics with cutting-edge multi-omics approaches, including bulk RNA-seq, single-cell RNA-seq, single-cell ATAC-seq, spatial transcriptomics, ChIP-seq, and CLIP-seq, to uncover the complex gene regulatory networks governed by transcription factors and RNA-binding proteins during cardiac development and disease.
Through these studies, we aim to define the molecular mechanisms underlying congenital and acquired heart diseases, including left ventricular noncompaction (LVNC), and to identify new therapeutic strategies for improving cardiovascular health.
About the PI Dr.
Tongbin Wu earned his B.S. and Ph.D. degrees from Wuhan University, where he trained under the mentorship of Dr.
Xiang-Dong Fu, a world-renowned scientist in RNA biology.
He then joined the University of California San Diego (UCSD) for postdoctoral training in the laboratory of Dr.
Ju Chen, a distinguished investigator in cardiovascular research.
In 2023, Dr.
Wu joined the Masonic Medical Research Institute (MMRI) as an Assistant Professor and established his independent research program.
His work focuses on uncovering the molecular mechanisms that govern heart development and disease, with a particular emphasis on RNA regulation and gene regulatory networks.
Dr.
Wu has made significant contributions to the field, publishing research articles in leading journals including Circulation, Circulation Research, Proceedings of the National Academy of Sciences (PNAS), and American Journal of Physiology-Heart and Circulatory Physiology.
Selected recent publications: https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.121.056666 https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.125.326948 https://journals.physiology.org/doi/full/10.1152/ajpheart.00135.2026 For more information, please visit our website
A recent or pending Ph.D. in the cardiovascular research or related fields. Proficient in molecular and cell biology techniques. Experience in small animal handling techniques. Experience in generating and analyzing next-generation sequencing (NGS) datasets. Demonstrated productivity in the form of first author publications and presentations Excitement to tackle difficult scientific questions in areas that will involve significant development of technical and analytical workflows Scientific creativity to identify novel approaches to answer our research questions A hard working and collegial attitude A desire to work in an informal, highly collaborative, and scientifically rigorous laboratory environment.
Market context
In New York, postdoctoral cardiovascular research roles are typically competitive because labs look for candidates who can contribute quickly to ongoing projects and publish independently. This role stands out for its mix of molecular and cell biology, NGS analysis, small animal work, and a first-author publication record; the listed requirements and benefits are AI-summarized from the original job description, saving you research time. If you are considering applying, review how your recent or pending PhD and publication history align with the lab’s methods before submitting.