City of Hope·Monrovia, California
Conduct independent and collaborative research on high-risk B-cell acute lymphoblastic leukemia using integrated genomic and experimental approaches. Design and execute wet-lab experiments to investigate molecular drivers, signaling pathways, and immune-related mechanisms of leukemogenesis.
Join the forefront of groundbreaking research at City of Hope where we are changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses.
Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.
The Beckman Research Institute of City of Hope invites applications for an outstanding and highly motivated Postdoctoral Fellow to join Dr.
Zhaohui Gu’s laboratory.
The Gu laboratory studies the molecular basis of high-risk B-cell acute lymphoblastic leukemia and other hematologic malignancies through integrated genomic and experimental approaches.
Research in the laboratory focuses on defining disease subtypes, identifying key molecular drivers, and elucidating mechanisms of leukemogenesis, clonal evolution, immune regulation, and treatment response using functional genomics, molecular biology, cell biology, immunology, and in vivo model systems.
For more information about Dr.
Zhaohui Gu’s lab, please visit: https://gu-lab.net and https://www.cityofhope.org/Zhaohui-Gu As a successful candidate, you will: Conduct independent and collaborative research in leukemia genomics, cancer biology, immunology, and hematologic malignancy research, with emphasis on high-risk B-cell acute lymphoblastic leukemia and related diseases.
Design and execute wet-lab experiments to investigate the biological functions of driver genetic alterations, dysregulated signaling pathways, and immune-related mechanisms in leukemia and other hematologic malignancies.
Perform molecular and cellular assays, which may include cell culture, flow cytometry, lentiviral transduction, CRISPR-based perturbation, qRT-PCR, western blotting, cloning, and other standard techniques in molecular and cellular biology.
Use sequencing-based and functional genomics approaches to characterize leukemic cells, immune cell populations, and normal hematopoietic populations.
Contribute to studies involving mouse models, xenograft models, or other relevant in vivo systems to investigate leukemogenesis, disease progression, leukemia-microenvironment interactions, immune regulation, and therapeutic response.
Collaborate with computational researchers to interpret genomic, transcriptomic, epigenomic, and immunologic datasets and to integrate experimental and sequencing-based findings.
Requires a Ph.D. in Biology, Genomics, Immunology, or a related biomedical discipline with a demonstrated record of peer-reviewed publications. Candidates should have strong hands-on experience in molecular and cellular biology techniques and the ability to interpret high-throughput molecular datasets.
Market context
California continues to be a strong market for postdoctoral research roles in cancer biology, especially in academic medical centers and research institutes focused on genomics and translational oncology. This type of fellowship is competitive because employers look for a Ph.D., peer-reviewed publications, and practical experience with molecular and cellular biology plus high-throughput data analysis. Review the AI-summarized requirements and benefits on this platform to quickly compare the posting with your publication record and methods experience before applying.
