Cedars-Sinai·West Hollywood, California
The Project Scientist will lead research projects on immune mechanisms driving neurodegeneration, specifically focusing on ALS and microglial biology. Responsibilities include managing day-to-day lab operations, analyzing complex genomic data, and contributing to publications and grant proposals.
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Cedars-Sinai offers scientists unparalleled access to ground breaking technologies, facilities, and resources for conducting research related to an impressive range of diseases and disorders, from cancer, cardiology, and digestive diseases, to genetics, genomics, neurosciences, and women's health.
Dr.
Bahareh Ajami invites you to consider this Project Scientist opportunity to join her dynamic team!
About the Team The Ajami Lab is establishing a new research program at Cedars-Sinai focused on immune mechanisms driving neurodegeneration, with a particular emphasis on ALS and microglial biology.
The Project Scientist works independently and in cooperation with the Principal Investigator to accomplish significant contributions to a research or project in any academic field. The incumbent may be an ongoing member of a research team or may be employed for a limited period of time to contribute high-level skills to a specific research program. Project Scientists are not required to carry out independent research or to develop an independent research reputation and do not have teaching responsibilities. Ordinarily, the Project Scientist title will carry out research or creative programs as well as administration of day-to-day lab operations with supervision by a member of the Professorial Series. This position is supported by a newly awarded NIH R01 investigating α5 integrin as a molecular switch regulating microglial and peripheral immune cell transitions in ALS. The successful candidate will lead projects integrating: Mouse models of ALS (e.g., mSOD1, conditional knockouts) Human iPSC-derived microglia and macrophage systems Single-cell and spatial genomics (CITE-seq, CODEX/PhenoCycler) Mechanistic studies of ECM–integrin signaling in neuroinflammation Primary
May assist in preparation of grant proposals, submissions, publications and presentations, but is not responsible for generating grant funds. May serve as PI for certain grants as approved by supervising member of the Professorial Series. May participate in publications and presentations as author or co-author. May develop, adapt and implement new research techniques and protocols. Assists in lab experiments. Analyzes, interprets, summarizes and compiles data. May lead or train Staff Research Associates and Research Fellows. Assists in day-to-day laboratory activities. Appointees on an academic trajectory will be expected to commit a portion of their time to developing an independent range of research.
A PhD or MD/PhD in Immunology, Neuroscience, or a related field is required, along with completed postdoctoral training. Candidates must demonstrate expertise in ALS research, a strong publication record, and experience with iPSC-derived systems and in vivo mouse models.
Market context
California research institutions often see steady demand for scientists with advanced training in neuroscience and immunology, especially for ALS-focused work. This role is competitive because it combines a PhD or MD/PhD, postdoctoral experience, a strong publication record, and hands-on work with iPSC-derived systems and in vivo mouse models. Before applying, compare your recent publications and model-system experience to the posting; the job requirements and benefits on this platform are AI-summarized from the original job description, saving candidates research time.
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