Research Fellow - Lab Medicine and Pathology

The candidate will be working under the mentorship of Dr. Maia and Dr. Harrington in a joint project to define transcriptional dependencies associated with serous (p53 Aberrant) endometrial cancer.

Responsibilities

• Cultivate mammalian cell cultures, primarily intestinal organoid/tumoroid models
• Derive and establish normal and cancer organoid lines frompatient samples
• Design and conduct drug screenings and evaluate the efficacy of novel therapeutics in preclinical organoid models.
• Use reporter expressing organoid models to assess cell state dynamics, in response to various compounds and drug candidates, using flow cytometry analysis.
• Conduct a wide range of molecular biology techniques, such as DNA/RNA extraction, PCR, qPCR, cloning, western blotting and chromatin immunoprecipitation (ChiP).
• Interpret, present, and document experiments based on generated data to investigators
• Maintain and report accurate records of data
• Experience with genomics techniques such as ATAC-seq, RNA-seq, ChiP-seq, CUT&RUN is preferred.
• Experience within vivo preclinical models of oncology is also preferred.

Why Mayo Clinic

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans [https://jobs.mayoclinic.org/benefits/] – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

Benefits

• Highlights
• Medical: Multiple plan options.
• Dental: Delta Dental or reimbursement account for flexible coverage.
• Vision: Affordable plan with national network.
• Pre-Tax Savings: HSA and FSAs for eligible expenses.
• Retirement: Competitive retirement package to secure your future.