Research Postdoctoral Fellow- Khandros Lab

SHIFT

• Any (United States of America) Seeking Breakthrough Makers Children’s Hospital of Philadelphia (CHOP) offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation. At CHOP, your experience is valued; your voice is heard; and your contributions make a difference for patients and families. Join us as we build on our promise to advance pediatric care—and your career. CHOP does not discriminate on the basis of race, color, sex, national origin, religion, or any other legally protected categories in any employment, training, or vendor decisions or programs. CHOP recognizes the critical importance of a workforce rich in varied backgrounds and experiences and engages in ongoing efforts to achieve that through equally varied and non-discriminatory means. A Brief Overview Under the direction/guidance of a mentor (principal investigator), assumes responsibility for a specific, on-going research project. The experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group. This role will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. This position will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings. This role also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab. About the Laboratory The Khandros lab is looking for a postdoctoral researcher to join our team in the Division of Hematology at the Children’s Hospital of Philadelphia. I am a physician scientist with a clinical focus on red blood cell disorders such as sickle cell disease and thalassemia. These diseases cause a significant amount of death and suffering in some of the lowest resource communities worldwide. Our research focus is on the mechanisms of hemoglobin gene regulation and red blood cell development, as well as developing novel therapeutics for these diseases. Our work involves a multi-disciplinary approach across the fields of developmental biology, molecular biology, and epigenetics, and we utilize cutting-edge multi-omics techniques, CRISPR screening, mouse disease models, and patient cell-based studies. One of the primary areas of study in the lab is re-activation of fetal hemoglobin in adult red blood cells, which is the key therapeutic approach in sickle cell disease.