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  3. Principal Scientist, Clinical Biomarker, Immunology & Immuno-Oncology (Hematology)
LB

Principal Scientist, Clinical Biomarker, Immunology & Immuno-Oncology (Hematology)

Legend Biotech US·Somerset, New Jersey

$146,410 - $192,164/yr·Full Time·Hybrid·5-10 yrs
·Posted 1 month ago
Practice for this role

About the role

Drive the clinical translational understanding and biomarker strategy for novel cell therapies focusing on hematological malignancies. Lead cross-functional teams to investigate mechanisms of action using high-dimensional molecular and cellular data.

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking a Principal Scientist, Clinical Biomarker, Immunology & Immuno-Oncology (Hematology) as part of the Early Drug Development team based in Somerset, NJ.

Role Overview

We are seeking a highly motivated and innovative Principal Scientist to join our immunology and immuno-oncology (IO) clinical biomarker projects, with a dedicated focus on hematological malignancies. In this role, you will drive the clinical translational understanding of novel therapy in hematology. You will serve as the biology lead on cross-functional project teams, drive MOA of novel cell therapy and clinical biomarker strategy.

Key Responsibilities • Scientific Leadership

  • Design, execute, and analysis results from clinical studies to investigate the mechanisms of action for novel IO targets in hematological indications (e.g., AML, DLBCL, Multiple Myeloma).
  • Translational
  • Strategy: Bridge discovery and clinical development by utilizing primary human samples and clinical datasets to validate targets and understand the immune microenvironment in hematology.
  • Understanding
  • MOA: Oversee the generation and interpretation of high-dimensional molecular and cellular data. Leverage advanced single-cell technologies (e.g., scRNA-seq) to deeply profile immune cell compartments, particularly T-cell states and exhaustion markers, to inform patient stratification and biomarker hypotheses.
  • Cross-Functional
  • Collaboration: Partner closely with other functional teams for better understanding of MOA and fundamental immunology.

Requirements

  • Ph.D. in Immunology, Immuno-Oncology, Cellular Biology, or a closely related discipline, can initiate and lead data driven MOA studies. Experience with cell therapy a plus but not required.
  • A minimum of 5-8+ years of post-doctoral and/or industry experience in biotech or pharma, with a proven track record of advancing IO programs. Deep understanding of immunology, particularly T cell biology highly desirable.
  • Hematology Expertise: Deep biological understanding of hematological malignancies and the unique tumor immune microenvironment of the blood and bone marrow.
  • Experience working with multiple dimensional data, extract biological insights from data highly desirable.
  • Exceptional written and verbal communication skills, with the ability to distill complex data into clear, actionable strategic decisions.

#Li-JR1

#Li-Hybrid

The base pay range below is what Legend Biotech USA Inc. reasonably expects to offer at the time of posting. Actual compensation may vary based on experience, skills, qualifications, and geographic location. The company reserves the right to modify this range as needed and in accordance with applicable laws.

Other Types of Pay

Performance-based bonus and/or equity is available to employees in eligible roles.

Benefits

and Paid Time Off: Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. We offer eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays. Additional voluntary benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide voluntary commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs; demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.

Pay Range (Base Pay): $146,410—$192,164 USD

Please note

These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.

Work Authorization & Employment Eligibility

Applicants must be authorized to work in the United States. As part of our commitment to maintaining a lawful workforce and ensuring compliance with federal employment regulations, we participate in the E-Verify program. If you are selected for employment, you will be required to complete the Form I-9 process, and your employment eligibility will be verified through E-Verify in accordance with applicable federal law. We are committed to providing a fair, transparent, and welcoming hiring experience for all candidates.

EEO Statement

It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.

For information related to our privacy notice, please review

Legend Biotech Privacy Notice [https://legendbiotech.com/privacy-notice/].

Posting details

Employment type
Full Time
Work arrangement
Hybrid
Experience
5-10 yrs
Salary
$146,410 - $192,164/yr
Location
Somerset, New Jersey
Posted
Jun 26, 2026
Application
Employer website
LB

Hiring organization

Legend Biotech US

Legend Biotech is a global, commercial-stage biotechnology company developing and manufacturing novel therapies. We explore and apply innovative technologies to deliver cutting-edge options for patients around the world. Our corporate headquarters is located in Somerset, NJ, and...

Salary listed on 1 job
IndustryBiotechnology Research
TypePublic Company
Size1,001-5,000 employees
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Market context

Competitive hematology biomarker roles in New Jersey

In New Jersey, principal scientist roles in clinical biomarker work for immunology and immuno-oncology are typically competitive because employers look for advanced training plus hands-on experience in hematologic malignancies and multi-dimensional data analysis. Candidates are often compared on depth of biological insight, translational thinking, and experience turning complex datasets into study decisions. Review the AI-summarized requirements and benefits here to save time, then tailor your application to show specific biomarker and hematology examples.

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