Children’s Hospital of Philadelphia·Philadelphia, Pennsylvania
Conduct independent scholarly research on leukodystrophy disease mechanisms and develop novel therapeutic approaches. Responsibilities include designing experiments, analyzing data, preparing manuscripts, and mentoring junior laboratory members.
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A Brief Overview Under the direction/guidance of a mentor (principal investigator), assumes responsibility for a specific, on-going research project. The experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group.
This role will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results.
This position will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings.
This role also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.
About the Laboratory The Leukodystrophy Center at the Children's Hospital of Philadelphia (CHOP) is seeking a Research Postdoctoral Fellow to participate in research focused on understanding disease mechanisms and developing novel therapeutic approaches for leukodystrophies.
The laboratory of Dr.
Adeline Vanderver investigates the pathogenesis and treatment of multiple leukodystrophies, including Hypomyelination with Atrophy of the Basal Ganglia and Cerebellum (H-ABC), Aicardi-Goutières Syndrome (AGS), Metachromatic Leukodystrophy, BLOC1S1-related Leukodystrophy, and Alexander Disease.
The laboratory utilizes a wide range of cutting-edge technologies, including transgenic mouse models, induced pluripotent stem cell (iPSC)-based disease models, live-cell imaging, spatial molecular profiling, and other advanced molecular and cellular approaches.
The successful candidate will support basic and translational research projects within the Leukodystrophy Center and will have opportunities to collaborate with leading investigators in the field, as well as access to a variety of training opportunities, career development programs, and mentorship resources designed to support scientific and professional growth.
The position offers participation in grant-funded research programs, manuscript preparation, and attendance and presentation at national and international scientific meetings.
The Research Postdoctoral Fellow will work independently within a highly collaborative and fast-paced research environment under the mentorship of Dr.
Adeline Vanderver and senior research scientists.
Responsibilities include designing and conducting experiments, maintaining accurate research records, analyzing and interpreting data, preparing manuscripts and scientific reports, and contributing to grant applications.
The Research Postdoctoral Fellow will also be expected to mentor junior laboratory members and assist in fostering a collaborative research environment.
Candidates should have a strong background in neuroscience, neurobiology, molecular biology, or a related field.
Experience with iPSC-based models, mouse models, gene therapy approaches, or leukodystrophy research is highly desirable, but not required.
What you will do Conduct independent scholarly research and develop new methods and protocols Participate in project planning, recording and evaluation of data Acquire technical, lab management and grant writing skills Participate in seminars, lectures, poster sessions and presentation at national meetings Supervise junior lab members Assist with other research projects Education Qualifications Doctorate - Required Skills and Abilities Ability to wear a respirator device
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$20,800.00 - $110,400.00 Annually Salary ranges are shown for full-time jobs. If you're working part-time, your pay will be adjusted accordingly. If you are applying for a Research Post-Doctoral Fellow role, please refer to this link for salary guidelines (copy & paste into your browser): https://www.research.chop.edu/services/hiring-a-postdoctoral-fellow#collapse-accordion-3523-3 ------------------- At CHOP, we are committed to fair and transparent pay practices. Factors such as skills and experience could result in an offer above the salary range noted in this job posting. Click here for more information regarding CHOP's Compensation and Benefits.
A doctorate degree in neuroscience, neurobiology, molecular biology, or a related field is required. Experience with iPSC-based models, mouse models, or gene therapy is highly desirable.
Market context
In Pennsylvania, postdoctoral research roles in neuroscience and rare-disease programs are often shaped by grant funding, lab priorities, and specialized expertise. This type of position is competitive because candidates with doctorate-level training plus hands-on experience in iPSC-based models, mouse models, or gene therapy can align closely with translational research needs. Review the AI-summarized requirements and benefits on this platform to save time, then tailor your application to the specific model systems and techniques you have used.
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