The Jackson Laboratory·Bar Harbor, Maine
The candidate will plan and execute an independent research project focusing on hematopoietic stem cell biology, aging, and hematologic malignancies. Additional duties include preparing manuscripts, applying for fellowships, and mentoring junior lab members.
A Postdoctoral Associate position is available in Dr. Jennifer Trowbridge’s laboratory [https://www.jax.org/research-and-faculty/research-labs/the-trowbridge-lab] at The Jackson Laboratory in Bar Harbor, Maine. The Trowbridge lab is dedicated to uncovering the fundamental mechanisms that govern hematopoietic stem cell (HSC) biology across three interconnected areas:
HSC aging – both the cell-intrinsic changes that accumulate over a lifetime and alterations that occur in the bone marrow microenvironment where these cells reside
Clonal hematopoiesis – understanding why somatic mutations in epigenetic regulatory genes (e.g., DNMT3A, TET2, ASXL1) are selectively expanded in HSCs with aging, and how they modify risk of aging-associated diseases
Hematologic malignancies – the mechanisms by which clonal hematopoiesis progresses to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML)
Our long-term goal is to identify intervention strategies that extend “healthspan” of blood stem cells – preserving their regenerative capacity into older age and reducing the risk of blood cancers. The multi-disciplinary nature of our work is highlighted our recent publications in Nature Communications (Young et al., 2025) and Nature (Hosseini et al., 2025) identifying elevated mitochondrial metabolism as a selective dependency of CH-mutant HSCs.
The Trowbridge lab offers a highly collaborative environment with strong national and international collaborations. Past and current trainees have been extremely successful in obtaining competitive grant funding and fellowships, and have gone on to independent positions in both academia and industry.
The successful candidate will be able to plan, develop, execute, and analyze an independent research project within one or more of the lab’s focus areas. Additional responsibilities include preparing manuscripts, fellowship applications, and conference presentations, mentoring junior lab members and contributing to a collaborative team environment.
A complete application must include a cover letter describing past research accomplishments, current research interests, and career aspirations; a current CV; and the names and contact information of three references.
Year 0 - 1: $65,589
Year 1 - 2: $67,318
Year 2 - 3: $69,095
Year 3 - 4: $70,521
Year 4 - 5: $72,877
Year 5 - 6: $75,569
Based on years of experience as Postdoc
The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute-designated Cancer Center and nearly 3,000 employees in locations across the United States (Maine, Connecticut, California), Japan and China. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.
Founded in 1929, JAX applies over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and provides critical data, tools and services to the global biomedical community. For more information, please visit [http://www.jax.org]www.jax.org [http://www.jax.org] http://www.jax.org.
The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.
A PhD or MD in biological sciences with at least one first-author publication is required. Preferred qualifications include experience in epigenetics, mouse HSC biology, CRISPR-based approaches, and bioinformatics.
Market context
Postdoctoral Associate roles in Maine are typically driven by active academic and biomedical research programs, where candidates with strong publication records and specialized lab skills are in demand. This role is competitive because it requires a PhD or MD in biological sciences plus a first-author publication, with preferred experience in epigenetics, mouse HSC biology, CRISPR-based approaches, and bioinformatics. Review the AI-summarized requirements and benefits here to quickly compare fit before applying, then tailor your materials to highlight your publication history and relevant methods experience.
