City of Hope·Duarte, California
Lead efforts in recombinant protein expression, purification, and structure determination using X-ray crystallography. Collaborate across structural biology and chemical biology to develop first-in-class modulators for metabolic pathways.
Join the forefront of groundbreaking research at City of Hope, where we are changing lives and making a meaningful impact in the fight against cancer, diabetes, and other life-threatening illnesses.
Our dedicated and compassionate faculty and staff are united by a shared mission: to contribute to innovative approaches that predict, prevent, and cure disease while helping shape the future of medicine through cutting-edge research.
The Dr.
Jeff Perry laboratory in the Beckman Research Institute of City of Hope is seeking a highly motivated postdoctoral fellow to join a multidisciplinary drug discovery program focused on a metabolic enzyme that plays a central role in cholesterol homeostasis and bile acid synthesis, with direct implications for metabolic disease and cardiometabolic risk.
As a successful candidate, you will: Lead efforts in recombinant protein expression and purification, and structure determination using X-ray crystallography to enable structure-guided ligand design.
Collaborate at the interface of structural biology, chemical biology, and translational therapeutics, contributing to the development of first-in-class modulators targeting a clinically relevant metabolic pathway.
A Ph.D. in life sciences or a related discipline is required, along with essential experience in protein biochemistry and X-ray crystallography. Experience in quantitative biophysical characterization and a track record of successful publications are highly desirable.
Market context
In California, postdoctoral roles in structural biology and drug discovery are typically driven by active research programs in universities, biotech, and translational labs. These positions are competitive because employers often look for a Ph.D., hands-on protein biochemistry and X-ray crystallography experience, and a publication record. Review the AI-summarized requirements and benefits here to save time, then tailor your application to highlight specific structures solved, methods used, and published work.
