ImmunEdge, Inc·Redwood City, California
Design and execute in vivo efficacy, PK/PD, and mechanistic studies in oncology and immunology murine models. Collaborate with cross-functional teams to analyze samples and develop ex vivo assays to inform translational strategies.
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ImmunEdge has an exciting opportunity for an Associate Scientist with strong hands-on in vivo experience, flow cytometry, and cell culture expertise to join our In Vivo Pharmacology team. This individual will play a key role in advancing preclinical oncology and immunology programs by designing, executing, and analyzing in vivo studies to support candidate selection, mechanistic studies, and translational strategy. Strong candidates will be highly collaborative, scientifically rigorous, and passionate about drug discovery and immune-mediated diseases. Experience working in a dynamic, early-stage biotech environment and contributing across discovery and translational workflows is highly valued.
Key
Responsibilities: Design, execute, and interpret in vivo efficacy, PK/PD, and mechanistic studies in relevant oncology and immunology models Effectively contribute to safety/toxicology studies and assessments in murine models Perform necropsies and tissue collection, process tissue and perform flow-cytometry based staining and sample acquisition Collaborate with discovery, translational, and biomarker teams to leverage study-derived samples and develop ex vivo mechanistic assays (MSD, bulk RNA-seq, scRNA-seq) that inform disease biology, mechanism of action and translational strategy. Contribute to study planning, experimental timelines, and data-driven decision making for program advancement Maintain accurate, well-organized experimental records while ensuring a safe, compliant, and reproducible lab environment Identify opportunities to improve in vivo platforms and evaluate emerging technologies relevant to ImmunEdge’s pipeline
Bachelor’s degree in biological science, with 8 years industry experience or Master's degree with 6 years industry experience in drug discovery or development, with significant hands-on experience in vivo models Demonstrated experience designing, executing, and interpreting studies in murine syngeneic and transgenic disease models, particularly in oncology and/or immunology Expertise in subcutaneous tumor implants and orthotopic surgeries is required Proficient in dose administration via multiple routes, including intraperitoneal, intravenous, tail vein and oral gavage Experience with blood collection (cheek bleed or RO), necropsy and sample processing in mice to support PK, PD, and biomarker analyses Experience in flow cytometry (immune phenotyping, data analysis). Prior experience with Cytek spectral cytometry instruments is a plus Experience in aseptic cell culture and perform cell line expansion for tumor implants in mice Proficiency with standard laboratory techniques such as ELISA, MSD, qPCR, western blotting, and cytokine bead array is a plus Demonstrated ability to independently analyze and interpret complex datasets using Flowjo, GraphPad Prism, generate publication-quality figures, and effectively communicate findings through slide presentations in departmental and cross-functional forums. Ability to independently plan and execute experiments, troubleshoot complex problems, and rigorously interpret scientific data Strong collaboration, communication, technical writing, and organizational skills Ability to thrive in a fast-paced, supportive start-up environment This is a position that requires working in a laboratory environment with biological and chemical hazards. Protective clothing, gloves, and safety glasses are required while working in the laboratory. This position requires the ability to lift containers or instruments up to 25 pounds and work standing at a fume hood or lab bench for extended periods. Expected
$119,000 - $128,000. We encourage candidates of all levels to apply as there is sometimes flexibility on job level and responsibilities. Compensation will be based on a variety of factors, including experience, qualifications, internal equity, and location. ImmunEdge offers a competitive employment package that includes an annual bonus plan, equity, and a generous benefits package including comprehensive health (medical, dental, and vision) insurance for our employees and their families, a 401k plan, FSA plans (medical, dependent), an Employee Assistance Plan, and a holiday and paid time off plan. At ImmunEdge, we believe that a diverse, open, and inclusive environment and culture is key to our success. We will not be influenced in recruiting, hiring, promoting or any other employment practices by race, color, citizenship status, national origin, ancestry, sex, sexual orientation, gender identity/expression, age, religion, physical or mental disability, medical or genetic condition, marital status, veteran status, or any other characteristics protected under applicable federal, state and local laws. ImmunEdge will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable laws. Note to External Recruiters: Submission of unsolicited resumes prior to an agreement set in place does not create any implied obligation.
Requires a Bachelor's degree with 8 years of industry experience or a Master's degree with 6 years of experience in drug discovery. Must have significant hands-on expertise in murine disease models, surgical implants, and flow cytometry.
Market context
In California, Associate Scientist roles in in vivo pharmacology are typically driven by ongoing demand in oncology drug discovery and preclinical research. These positions are competitive because employers often look for hands-on experience with oncology models, mammalian cell culture, syngeneic or xenograft systems, and molecular biology assays. Review the AI-summarized requirements and benefits here to save time, then tailor your application to match the specific model systems and assay experience listed in the original posting.
