Job detail

Post Doctoral Associate- Dr. Amantha Thathiah Lab

University of Pittsburgh

#Neuroscience #Translational Research #Biochemistry #Immunohistochemistry #Alzheimer's Disease #Genomics #Neurobiology #Murine Models #Proteomics

Quick overview

Investigate molecular and cellular mechanisms of Alzheimer's disease progression using human-derived neurons, glial models, and murine models. Lead projects focusing on either neuroimmune signaling via GPR3 or the mechanisms of tau pathobiology using optogenetic models.

Requirements summary

Candidates must hold a PhD in neuroscience, biology, or a related field with expertise in sterile tissue culture and confocal microscopy. Experience with iPSC reprogramming, molecular biology techniques, and mouse handling is highly preferred.

postgraduate degreeCloningScientific WritingImmunohistochemistryMolecular BiologyRNA IsolationProtein IsolationMouse HandlingImmunocytochemistryProteomic AnalysisConfocal MicroscopyWestern Blot AnalysisBehavioral ApproachesSterile Tissue CultureIPSC ReprogrammingSingle-cell AnalysisWhole-genome Analysis

Job description

The Thathiah Lab in the Department of Neurobiology at the University of Pittsburgh School of Medicine is recruiting two highly motivated postdoctoral associates to investigate the molecular and cellular mechanisms involved in Alzheimer's disease (AD) progression.
Our lab studies AD mechanisms across molecular, cellular, and systems levels using human-derived induced neurons (iNs), glial models, and pre-clinical murine models.
We integrate novel technologies to address hypothesis-driven questions in AD pathophysiology and advance the discovery of new therapeutic approaches.
We seek individuals passionate about neuroscience and translational disease research who want to work in a collaborative, innovative environment and contribute to cutting-edge research with direct implications for AD therapies.
Description of the Positions Neuroimmune Communication in Alzheimer's Disease.
The first postdoctoral associate will lead an exciting, NIH-funded project investigating the role of neuroimmune signaling in AD.
Specifically, the focus will be on our recent discovery of the G protein-coupled receptor (GPCR), GPR3, which is highly expressed in glial cells and may activate neuroprotective responses to AD pathology.
This position offers the opportunity to study how neuroimmune interactions modulate disease progression in AD.
Mechanisms of Tau Pathobiology in Alzheimer's Disease and Other Tauopathies.
The second postdoctoral associate will spearhead an ongoing project to investigate the molecular mechanisms underlying pathological tau phosphorylation and aggregation.
The lab has recently developed an optogenetic model of tau aggregation (optoTAU) that provides a unique platform for exploring tau aggregation across multiple cell types, including neurons, astrocytes, and oligodendrocytes.
This project will focus on the cellular and molecular modifiers and the consequences of tau aggregation to better understand its role in AD pathogenesis.
Qualifications and Expectations The ideal candidates will have: A recent Ph.D. in neuroscience, biology, biochemistry, or a related field with a strong publication record Expertise in sterile tissue culture techniques (required) Experience with IPSC reprogramming and disease modeling (preferred) Proficiency with molecular biology techniques (e.g., RNA isolation and cloning) Experience with biochemical approaches (e.g., protein isolation and Western blot analysis) Experience with confocal microscopy (required) Experience with immunocytochemistry and immunohistochemistry (preferred) Experience with single-cell, whole-genome, and proteomic analysis (preferred) Experience with mouse handling, including injection, dissection, and behavioral approaches (preferred) Excellent verbal and written communication skills, technical expertise, and scientific creativity are essential.

Post Doctoral Associate- Dr. Amantha Thathiah Lab

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