Job detail

Postdoctoral Research Associate - Chemical Biology & Therapeutics

St. Jude Children's Research Hospital

#Predictive Models #Synthetic Organic Chemistry #Automated Synthesis #Mass Spectrometry #Chemical Biology #Therapeutics #Postdoctoral Research Associate #St. Jude Children’s Research Hospital

Quick overview

The postdoctoral associate will leverage high-throughput chemical synthesis and MS/MS analysis to develop predictive models of chemical reactivity. The project involves connecting chemical structures to optimal reaction conditions using rapid tandem mass-spectrometry methods.

Requirements summary

Candidates must hold a PhD in Organic Chemistry. Experience with automated synthesis or high-throughput experimentation is highly desirable.

postgraduate degreePredictive modelingSynthetic organic chemistryTandem mass spectrometryHigh-throughput experimentationChemical reactivity analysisChemical biologyAutomated synthesisData-rich experimentation

Job description

A postdoc position is available immediately in the laboratory of Dr. Daniel Blair which focuses on leveraging high-throughput chemical synthesis and MS/MS analysis to create predictive models of chemical reactivity. Substrate aware reaction condition prediction This project seeks to capitalize on our recent development of rapid tandem mass-spectrometry methods to scout chemical reaction outcomes (Nature 2024, JACS 2026, Nature Protocols 2026). The proposed data rich experimentation will connect chemical structures to optimal reaction conditions. A competitive candidate will have a background in synthetic organic chemistry, experience with either automated synthesis or high-throughput experimentation is desirable. The project will be executed in the Department of Chemical Biology and Therapeutics at St. Jude Children’s Research Hospital and builds on strong investments into a world-class infrastructure in high-throughput chemical synthesis and analysis. Please direct queries and application packets including a cover letter, current CV, and contact information for 3 referees to Dr. Daniel Blair (daniel.blair@stjude.org). Papers/Links: U Neelakantan, … D J Blair
Generalized Analysis of Electrophilic Small Molecules, ChemRxiv 2026 doi: 10.26434/chemrxiv.10001482/v1 M Hu*, D J Blair
High-throughput reaction screening using acoustic ejection mass spectrometry, Nature Protocols 2026 doi: 10.1038/s41596-025-01320-y M Hu, … D J Blair
Direct-to-Biology Enabled Molecular Glue Discovery JACS 2026 doi: 10.26434/chemrxiv-2025-4d7nq M Hu… D J Blair
Continuous Collective Analysis of Chemical Reactions Nature 2024 doi: 10.1038/s41586-024-08211-4 https://www.science.org/content/blog-post/real-high-throughput-chemistry-through-mass-spec Minimum Experience PhD in Organic Chemistry St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

Postdoctoral Research Associate - Chemical Biology & Therapeutics

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