The associate researcher will conduct laboratory experiments focusing on human brain development and neuropsychiatric disease using stem cell-derived organoids. Responsibilities include generating samples for multiomic analyses and characterizing hippocampal organoid systems to study disease biology.
Requirements summary
Candidates must hold a B.S. or B.A. in a STEM-related field and possess basic knowledge of molecular biology and cell culture techniques. Strong organizational skills and a willingness to learn specialized organoid methodologies are essential for this role.
The laboratory studies human brain development and neuropsychiatric disease using stem cell–derived organoids and primary fetal tissue. Current projects focus on: Defining how radial glia give rise to hippocampal and neocortical lineages, and identifying signaling pathways (e.g., Wnt and beyond) that govern hippocampal subfield specification Building and characterizing human hippocampal organoid systems, including efforts to engineer missing subfields (e.g., CA1/CA3/DG) Identifying conserved molecular and cellular programs across genetic and pharmacologic models of schizophrenia using large-scale single-cell and multiomic datasets Modeling neurodevelopmental contributions to schizophrenia through perturbation systems, including chronic and acute NMDA receptor inhibition (e.g., ketamine exposure) Generating samples for large-scale single-cell and multiomic analyses The long-term goal is to establish a reproducible, high-throughput human organoid platform that enables mechanistic dissection of brain development and convergent disease biology.
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