Washington University in St. Louis
Location
St. Louis, Missouri
The role involves leading research initiatives in precision cardiovascular medicine using iPSC-derived cells and functional genomics. The associate will develop models to predict drug effects and uncover genetic drivers of cardiovascular toxicity.
A Ph.D. or M.D. is required, along with a track record of research productivity in peer-reviewed journals. Expertise in stem cell biology, functional genomics, or cardiovascular physiology is highly preferred.
The Shen Lab within the Division of Cardiology and Department of Medicine at WashU Medicine in St. Louis, USA, is recruiting for a Postdoctoral Research Associate. Our lab specializes in precision cardiovascular medicine, leveraging cutting-edge approaches such as human iPSC-derived 2D cardiovascular cells, 3D vascularized cardioids, CRISPR gene editing, high-throughput CRISPRko/i/a screening, single-cell multiomics, tissue engineering, and animal models. Our current research primarily focuses on four key areas: 1) Developing robust, chemically defined differentiation protocols to generate diverse cardiovascular cell types from iPSCs, enabling advanced cardiovascular disease modeling and cell therapy applications (Nature Cardiovascular Research 2023; Circulation 2023; Circulation Research 2021, Circulation 2019), 2) Uncovering genetic drivers of anti-cancer drug-induced cardiovascular toxicity through integrated iPSC models and high-throughput CRISPRi/a screening (Cell Stem Cell 2024), 3) Deciphering pathogenic coding and non-coding variants linked to congenital heart disease in a cell type-specific manner (Cell 2022), and 4) Combining iPSC-derived cells and single-cell perturb sequencing to establish foundational models to predict the effects of potential drug candidates on cardiovascular diseases. By combining genome engineering, functional genomics, and tissue models, we aim to advance mechanistic insights and therapeutic strategies for cardiovascular diseases. We are seeking highly motivated, creative postdoctoral fellows to drive innovations in cardiovascular precision medicine. We welcome candidates with expertise in iPSC biology, functional genomics, developmental biology, cardiovascular disease, and/or bioinformatics to explore the intersection of cardiovascular physiology, cancer biology, and regenerative medicine. This position offers the opportunity to develop translational research projects using cutting-edge approaches in a dynamic, interdisciplinary environment. Our lab provides a collaborative and supportive culture that champions teamwork, scientific curiosity, and innovation. Successful candidates will lead impactful research initiatives while receiving personalized mentorship to foster their growth as independent investigators. We are committed to your career success, offering dedicated support for fellowship applications, training grants, and transition to independence, along with opportunities to develop leadership and mentoring skills. WashU offers outstanding research infrastructure and professional development resources through its Career Center, Teaching Center, and Office of Postdoctoral Affairs. As part of our vibrant scientific community, you will have access to state-of-the-art facilities and a network of interdisciplinary collaborators.
Job Description: Primary
Information on being a postdoc at WashU in St. Louis can be found at Working Conditions: This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.
Base pay is commensurate with experience. The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time. Required Qualifications Education: Ph.D., M.D. Or Equivalent Terminal Or Doctoral Degree. Certifications/Professional Licenses: No specific certification/professional license is required for this position. Work Experience: No specific work experience is required for this position.
A track record of research productivity, as evidenced by first-authored original publication(s) in high-quality peer-reviewed journals. Expertise in one or more of the following areas: stem cell biology, functional genomics, cell biology, and cardiovascular physiology. Experience or interest in programming languages such as R or Python. Independence to lead a project as well as willingness to work in a team. An open mind to learn new methods from other researchers and collaborators. Good scientific presentation and writing skills.
Education: No additional education unless stated elsewhere in the job posting. Certifications/Professional Licenses: No additional certification/professional licenses unless stated elsewhere in the job posting. Work Experience: No additional work experience unless stated elsewhere in the job posting.
Cardiovascular Physiology, Cell Biology, Functional Genomics, Professional Presentation, Professional Writing, Python (Programming Language), R Programming, Stem Cell Biology, Teamwork Questions For frequently asked questions about the application process, please refer to our External Applicant FAQ. Accommodation If you are unable to use our online application system and would like an accommodation, please email CandidateQuestions@wustl.edu or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request. All qualified individuals must be able to perform the essential functions of the position satisfactorily and, if requested, reasonable accommodations will be made to enable employees with disabilities to perform the essential functions of their job, absent undue hardship. Pre-Employment Screening All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening. Benefits Statement Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits. EEO Statement Washington University in St. Louis is committed to the principles and practices of equal employment opportunity. It is the University’s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, citizenship (where prohibited by federal law), age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information. Q: Can I create a job alert to notify me when jobs of interest are posted? A: Yes! After you create a Candidate Home account, you can set up and manage job alerts to be sent to you either daily or weekly, according to the filters you select. You can add, edit, or delete job alerts at any time. You will need to opt in to communications from WashU when you set up your first alert and will only receive alerts for jobs posted after the alert has been created. Set alerts today so you do not miss any new opportunities! Washington University in St. Louis' collective success is significantly attributed to the passion and outstanding efforts of our community. Our staff, faculty and trainees are committed to excellence and dedicated to carrying out our missions of research, teaching and patient care. WashU prides itself on being a place where people matter, and serious work is done. Our people work together in an inclusive community that celebrates diverse perspectives, collaboration and innovation. We are a community of individuals inspired to work together to develop big ideas and tackle challenging problems. We value the well-being of our people. WashU strives to create a positive employee experience where staff, faculty and trainees thrive, both personally and professionally. Our employees find meaning, connection and vitality in their work and life with a healthy work-life balance and support to learn, grow and make an impact at WashU, the community and the world. Useful Links
Human Resources Benefits Living in St. Louis Frequently Asked Questions Accommodation If you are unable to use our online application system and would like an accommodation, please email CandidateQuestions@wustl.edu or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request. Regulatory Postings Know Your Rights: Workplace Discrimination is Illegal Poster (English; Spanish)
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