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The fellow will lead a translational research project on chemotherapy-induced peripheral neuropathy using breast cancer models and immune manipulations. Responsibilities include executing complex behavioral assays, performing molecular analysis, and disseminating findings through manuscripts and grants.
Requirements summary
A PhD or equivalent degree is required for this position. Candidates must possess advanced methodological expertise in immunology, neuroscience, and oncology research techniques.
Information: full-time Pay Range $30.70 - $46.05 This Postdoctoral Fellow position is essential for the successful execution of a highly technical, multi aim translational research project focused on uncovering immune mechanisms underlying chemotherapy induced peripheral neuropathy (CIPN) in the context of breast cancer treatment. The proposed research integrates complex orthotopic tumor models, immune specific genetic manipulations, advanced neurobehavioral phenotyping, and translational pharmacologic interventions, all of which require a dedicated, full time postdoctoral scientist with advanced methodological and analytical expertise. PhD or equivalent required. Scope of the Position and Key Functions The Postdoctoral Fellow will serve as the primary experimental lead and integrator across all three Specific
Aims of the project, with responsibilities including but not limited to: 1. Experimental Design and Execution
Lead and coordinate immunocompetent, orthotopic breast cancer resection models combined with adjuvant chemotherapy.
Perform immune specific genetic and pharmacologic manipulations targeting the IRE1α XBP1 pathway.
Conduct advanced flow cytometry, FACS sorting, molecular assays (qPCR, ELISA), histology, and confocal imaging. 2. Mechanistic and Translational Integration
Integrate tumor progression endpoints (recurrence, lung metastases, IVIS imaging) with neurotoxicity and immune outcomes.
Perform ex vivo co culture assays linking immune cell activation to neuronal injury and tumor aggressiveness.
Evaluate translational pharmacologic strategies (MKC 8866 ± paclitaxel) across multiple disease contexts. 3. Data Analysis, Interpretation, and Dissemination
Analyze high dimensional data across behavioral, molecular, immune, and oncologic endpoints.
Benefits
Dental Insurance
Life Insurance
Paid Parental Leave
Paid Time Off
Vision Insurance
Medical Insurance
Short-Term Disability
Long-Term Disability
Flexible Spending Accounts
Adoption Assistance
Educational Assistance Program
Retirement Plans With Employer Match
Prepare manuscripts, conference presentations, and progress reports for funding agencies.
Contribute to grant development supporting continuation and expansion of the research program. 4. Research Training and Mentorship
Provide day to day mentorship to trainees (graduate students and research staff) in specialized techniques.
Foster cross disciplinary collaboration between cancer biology, immunology, neuroscience, and anesthesiology.
Our
Commitment to
You:
Advocate
Health offers a comprehensive suite of
Total
Rewards: benefits and well-being programs, competitive compensation, generous retirement offerings, programs that invest in your career development and so much more – so you can live fully at and away from work, including: Compensation Base compensation listed within the listed pay range based on factors such as qualifications, skills, relevant experience, and/or training Premium pay such as shift, on call, and more based on a teammate's job Incentive pay for select positions Opportunity for annual increases based on performance Benefits and more Paid Time Off programs Health and welfare benefits such as medical, dental, vision, life, and Short- and Long-Term Disability Flexible Spending Accounts for eligible health care and dependent care expenses Family benefits such as adoption assistance and paid parental leave Defined contribution retirement plans with employer match and other financial wellness programs
Educational
Assistance
Program
Note: Eligibility for programs listed above may depend on your FTE or status (e.g., full-time, part-time, per diem, temporary, etc.); please ask a Recruiter for more information during an interview. About Advocate Health Advocate Health is the third-largest nonprofit, integrated health system in the United States, created from the combination of Advocate Aurora Health and Atrium Health. Providing care under the names Advocate Health Care in Illinois; Atrium Health in the Carolinas, Georgia and Alabama; and Aurora Health Care in Wisconsin, Advocate Health is a national leader in clinical innovation, health outcomes, consumer experience and value-based care. Headquartered in Charlotte, North Carolina, Advocate Health services nearly 6 million patients and is engaged in hundreds of clinical trials and research studies, with Wake Forest University School of Medicine serving as the academic core of the enterprise. It is nationally recognized for its expertise in cardiology, neurosciences, oncology, pediatrics and rehabilitation, as well as organ transplants, burn treatments and specialized musculoskeletal programs. Advocate Health employs 155,000 teammates across 69 hospitals and over 1,000 care locations, and offers one of the nation’s largest graduate medical education programs with over 2,000 residents and fellows across more than 200 programs. Committed to providing equitable care for all, Advocate Health provides more than $6 billion in annual community benefits. This is Transformation One shared purpose brought us together. Now, as one of the 10 largest not-for-profit, integrated health systems in the United States, our combined strength and stability drives us forward. Starting with You Caring for nearly 3 million people has inspired a transformation. One in which the patient’s experience guides our vision and empowers us to offer new possibilities in our communities. Reshaping Access What is access? It’s offering more sites of care than any other health system in the Midwest. But there’s a new frontier. Access is exploring the latest technologies to deliver care to patients exactly where they are and exactly when they need it Inspiring Professionals With our dynamically inclusive workforce and strong connections to the places where we live and work, we’ll touch more lives and contribute to stronger and more vibrant communities. Transforming Care We’re redefining the standard for care with world-class doctors and caregivers, innovative solutions, outstanding outcomes, and leading-edge research and clinical trials.
Combined,
Advocate and
Aurora are recognized for clinical excellence in: Cardiovascular Care Neurosciences Gynecology Oncology Pediatrics Primary Care Neurology Geriatrics Trauma Care
