Bristol Myers Squibb·San Diego, California
Develop oncology and immune-oncology disease models to support lead identification and mechanism-of-action studies. Design and execute in vivo efficacy and PK/PD experiments, analyzing data and presenting findings to multidisciplinary discovery teams.
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Summary The Pharmacology group within the Protein Homeostasis Thematic Research Center (TRC) at BMS San Diego provides in vivo pharmacology support to discovery teams focused on developing small molecules and biologics for oncology and immune-oncology.
As an integral part of discovery programs, the group supports lead identification through in vivo model screening and mechanism-of-action studies, develops and validates animal disease models, identifies pathway biomarkers, and establishes clinically relevant endpoints to assess efficacy.
Collaboration with DMPK, Exploratory Toxicology, and Translational Development is central to our work, and we contribute preclinical data to inform clinical development plans.
We are seeking a motivated Associate Scientist with broad experience in pharmacology and drug discovery for both small and large molecules.
The successful candidate will work collaboratively in a multidisciplinary environment, taking responsibility for experiment design, planning, and execution.
Key duties include interpreting and presenting in vivo data, conducting sample and endpoint analyses (ELISA, Western blot, Jess, qPCR, IHC), and preparing protocols and reports.
The role requires independent work, technical expertise, and contributions to project decisions.
Strong communication, self-motivation, innovation, flexibility, and teamwork are essential.
Position Responsibilities In the role as an Associate Scientist within Pharmacology, the ideal candidate will be responsible for the following: Develop disease models for oncology and immune-oncology Independently design and execute in vivo efficacy and PK/PD experiments to identify drug candidates Analyze and interpret data accurately, reporting findings to supervisors and colleagues Troubleshoot routine issues and recommend solutions Evaluate endpoints from in vivo studies using Western blots, mesoscale, qPCR, etc.
Write precise protocols and technical reports Present data to multidisciplinary discovery teams Collaborate with cross-functional team members Basic Qualifications: Bachelor’s Degree 2+ years of academic and / or industry experience with oncology models
Experience in mammalian cell culture Experience in the development of syngeneic and xenograft cancer models Proficient in animal handling, dosing (PO, IP, IV, and SC), tumor cell inoculation, data collection and analysis Hands-on experience in small animal surgeries, necropsy and tissue and blood collection Hands-on experience in evaluating small molecules in animal models Experience with small animal imaging modalities (e.g., Xenogen, ultrasound etc.) is a plus. Skilled in Western blots, ELISA, MesoScale, IHC, flow cytometry, RNA/DNA extraction, and PCR Proficient in Excel, Word, PowerPoint, FlowJo, GraphPad Prism, and Studylog Excellent interpersonal, communication, presentation, collaboration, and organizational skills Detail-oriented, focused, and able to deliver high-quality data efficiently #LI-Onsite If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Compensation Overview: San Diego - CA - US: $93,230 - $112,970 The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.
Requires a Bachelor's degree and at least 2 years of experience with oncology models. Preferred qualifications include expertise in mammalian cell culture, syngeneic/xenograft models, and various molecular biology assays.
Market context
In California, Associate Scientist roles in in vivo pharmacology are typically driven by ongoing demand in oncology drug discovery and preclinical research. These positions are competitive because employers often look for hands-on experience with oncology models, mammalian cell culture, syngeneic or xenograft systems, and molecular biology assays. Review the AI-summarized requirements and benefits here to save time, then tailor your application to match the specific model systems and assay experience listed in the original posting.