Prelude Therapeutics Incorporated
Location
Wilmington, Delaware
The role involves designing and executing wet-lab experiments to advance early-stage oncology drug discovery programs. Key duties include target identification, validation, and the development of robust assays to support therapeutic strategies.
Candidates must hold a Ph.D. in Cancer Biology, Molecular Biology, or a related field with 2-5 years of post-doctoral or 0-3 years of industry experience. Strong expertise in oncology biology and hands-on experience with molecular and cell-based assays are required.
We are seeking a highly motivated and innovative Scientist/Senior Research Scientist to join our Oncology Drug Discovery team in a hands-on, laboratory-based role. This individual will play a key role in advancing early-stage discovery programs, from target validation through lead optimization and translational research, with a focus on developing novel therapeutics for cancer treatment. This is a wet-lab bench position, where the successful candidate will design and execute experiments directly and independently, generate high-quality data, and contribute to scientific strategy. The ideal candidate brings deep experimental expertise, a collaborative mindset, and a strong track record of translating biological insights into therapeutic strategies. Key Responsibilities · Independently design and execute hands-on wet-lab experiments, including cell-based and molecular assays, to support oncology drug discovery programs. · Drive novel target identification and validation, including mechanistic studies, to support strategic decision-making across discovery programs. · Lead and perform in vitro and in vivo studies, independently generating and analyzing experimental data. · Design, develop, and optimize robust cell-based or biochemical assays to support target validation and drug discovery efforts. · Compile, analyze, and clearly present experimental and scientific data to the biology team to support scientific discussions and decision-making. · Interpret complex datasets and provide scientific insights to the biology team. · Perform independent literature review to guide experimental design and apply findings to support hands-on research and program progression. · Identify and implement cutting-edge technologies and experimental approaches. · Maintain detailed experimental records and ensure high-quality, reproducible data generation. · Collaborate closely within the biology team and interface with chemistry, translational, bioinformatics, and other interdisciplinary teams.
· Ph.D. in Cancer Biology, Molecular Biology or related field.· 2-5 years of relevant post-doctoral experience and/or 0-3 years pharmaceutical industry experience.· Strong background in oncology biology.· Significant hands-on experience with a broad range of cell-based assays and molecular techniques.· Strong analytical and communication skills.
· Experience with small molecules, targeted protein degradation, or biologics research and/or drug discovery.
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